GPT-4.5 could be days away

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Welcome back, Superhuman. Five percent of the world’s population now uses ChatGPT each week, but OpenAI isn’t stopping there. All signs point to the startup releasing GPT-4.5 in a matter of days — with GPT-5 not far behind.

Today’s Insights

• Microsoft’s new bio model, Crunchbase’s AI pivot, and a tiny video model

• Frontier: GPT-4.5 could be days away

• Tutorial: How to use AI as your personal email assistant

• 5 new AI tools to boost your productivity

• News, memes, what’s trending on socials, and more

TODAY IN AI

1. Microsoft’s new model accelerates protein research: The new open-source deep learning model is called BioEmu-1 and Microsoft claims it can match the accuracy of supercomputer simulations by generating thousands of protein structures per hour on a single chip. By providing researches faster and more accurate predictions into how proteins function, the model paves the way for further advancements in areas like drug development.

2. Crunchbase’s new AI tool predicts which startups will succeed: At least 75% of VC-backed startups fail. But Crunchbase, a go-to source for financial information, says it’s using AI to make investing in them a little less perilous. Its new model, trained on 17 years of data, can forecast which startups are likely to get funding with up to 95% accuracy. Last year, it predicted that productivity startup Coda was bound to be acquired — and sure enough, it was purchased by Grammarly just two months later.

3. Hugging Face unveils model small enough to ‘run on your toaster’: The AI platform just dropped a family of open-source VLMs called SmolVLM2 that it claims are the “smallest ever released.” One 500M-parameter version is so tiny it can run locally on your phone. It can analyze all kinds of visual information — from complex diagrams to text in photos — with comparable performance to its rivals, while coming in a much smaller package.

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FROM THE FRONTIER

OpenAI’s GPT-4.5 could drop before the end of the month

OpenAI isn’t going to let Elon Musk have the final word: xAI made the daring move earlier this week to temporarily hand out Grok 3 — allegedly the “smartest AI on earth” — to everyone at no cost, sending Grok straight to the App Store’s #1 slot. But Microsoft, OpenAI’s main server provider, is already battening down the hatches for GPT 4.5, which could release as soon as next week.

What to expect: The new model is likely to sweep the charts across coding, math, and reasoning. But as the startup’s final non-chain-of-thought release, it also represents an end of an era. GPT-5, reportedly set to come out in late May, will bring all of ChatGPT’s features — from deep search to web browsing to the agentic Operator tool — under one roof.

It’s been an uphill battle: Ex-CTO Mira Murati recently scooped up 20 OpenAI engineers for her new startup. CEO Sam Altman fended off a $97B bid from Musk last week. And DeepSeek gave the startup a run for its money with R1. Despite all of that, COO Brad Lightcap says OpenAI just reached a new milestone: It now has 400M weekly active users — more than the entire US population. Can it keep up the momentum? The next couple weeks could be its sink or swim moment.

THE AI ACADEMY

How to use AI as your personal email assistant

• Go to Fyxer AI and sign up with your account.

• Personalize your executive assistant by selecting ‘Categorize inbox’, ‘Draft replies’, and ‘Summarize meetings’ buttons.

• Click on ‘Connect Gmail’ and grant access to your calendar, events, and emails. Wait for it to sync.

• Your emails will be categorized into folders so you never miss the important ones.

• It will also draft convincing replies for you in any language.

• You can connect it to your Zoom to get meeting summaries.

• It gets better with time as it learns more about your business using AI.

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7 key AI and LLM predictions from Google’s Director of AI

Read the 7 key takeaways from Google’s Director of AI and Datadog’s VP of Engineering on their predictions for the future of AI, LLMs, and Observability on Google Cloud:

• How to better leverage AI/LLMs

• Building customer confidence with LLM output

• Tips to evolve tooling as LLM use grows

Learn the insights here.

AI & TECH NEWS

Everything else you need to know today

🤖 On-the-Job Training: Figure’s new Helix platform helps its humanoid robots “reason like humans,” letting them handle nearly any household object, including ones they’ve never seen before. (Check back tomorrow for a deeper dive in our robotics newsletter.)

🤳 Lens Leap: iOS users can now draw, tap, or highlight any text or image from their camera lens or screen to learn more about it via Google Lens.

💬 Voice Venture: Spotify teamed up with ElevenLabs to bring more AI-narrated audiobooks to the streaming platform.

🧏 Language Lab: Nvidia and the American Society for Deaf Children launched a new AI platform called Signs that can help people learn American Sign Language, the third most prevalent language in the US.

💰 Funding: Mercor, which uses AI to streamline companies’ hiring practices, raised $100M in a Series B round. And the Salesforce and Nvidia-backed compute startup Together AI raised $305M in a new deal that values the company at $3.3B. Finally, AI coding startup Codeium is raising new funding at a $2.85B valuation, more than doubling its value in just the past six months.

PRODUCTIVITY

5 AI Tools to Supercharge Your Productivity

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PROMPT OF THE DAY

Plan meals for fitness goals

Prompt: As a nutritionist and fitness expert, create a detailed meal plan to help achieve [specific goal]. The meal plan should be balanced and nutritious, taking into account the necessary daily intake of proteins, carbohydrates, and fats. It should include meal and snack suggestions for each day of the week, along with portion sizes. Additionally, provide a list of foods to avoid. Make sure the meal plan is sustainable and easy to follow, allowing for some flexibility.

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SOCIAL SIGNALS

What’s trending on socials today

💡 Eureka Moment: Harvard biologist David Sinclair, known for his efforts to extend the human lifespan, says he just used Grok 3 to “solve a key scientific problem” — although he won’t reveal the details yet.

🔍 Between the Lines: Commentator Prakash Narayanan decoded Microsoft CEO Satya Nadella’s recent comments on the Dwarkesh podcast, including why Nadella might not really “believe in AGI.”

📹 Remix Reality: Pika’s new Pikaswaps feature lets you replace any video subject with something else — letting you do things like instantly turn your dog into a giant lizard.

🛠️ Do It Yourself: Entrepreneur Alex Finn showed how he built a real-time news app with Grok. Or, if video games are more your thing, he made a tutorial for that, too.

AI-GENERATED IMAGES

Peek And Play

Midjourney Prompt: A black cat peeking out from behind a green wall, in a cartoon style. The cat has big, cute eyes and a cute expression, set against a yellow background. This high-definition wallpaper features a cute cartoon animal illustration in high resolution. --ar 9:20

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Zain & the Superhuman AI team